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Who should avoid GHK-CU Wilson's disease or copper metabolism disorders Active malignancies (until more research exists) Pregnancy and breastfeeding Known copper sensitivity or allergy Those unable to maintain sterile injection technique When uncertain, consult a healthcare provider familiar with peptide research

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Where possible, SARS-CoV-2 vaccination should be administered while patients are taking the lowest dose of systemic corticosteroid[113]

"We cannot recommend peptide therapies that lack regulatory approval and adequate clinical trial evidence," stated the AACE 2023 obesity guideline update, which specifically addressed the proliferation of unapproved compounded peptides for weight management [9]